![NICE recommends tepotinib as the first oral MET inhibitor treatment as an option for adult patients with advanced NSCLC with METex14 skipping alterations - ecan NICE recommends tepotinib as the first oral MET inhibitor treatment as an option for adult patients with advanced NSCLC with METex14 skipping alterations - ecan](https://cdn.ecancer.org/20014-m.jpg)
NICE recommends tepotinib as the first oral MET inhibitor treatment as an option for adult patients with advanced NSCLC with METex14 skipping alterations - ecan
![MET TKIs in METex14+ NSCLC: Tepotinib - Downloadable Slidesets - MET Inhibition in NSCLC - Oncology - Clinical Care Options MET TKIs in METex14+ NSCLC: Tepotinib - Downloadable Slidesets - MET Inhibition in NSCLC - Oncology - Clinical Care Options](https://www.clinicaloptions.com/-/media/oncology/programs/nsclc-metex14/cco_nsclc_metex14_downloadable_2_thumb.png?rev=05a641b272384c329b3ced779616d60f&h=166&w=295&la=en&hash=CB59A475641384447E096A6E7F0944FD6941CED9)
MET TKIs in METex14+ NSCLC: Tepotinib - Downloadable Slidesets - MET Inhibition in NSCLC - Oncology - Clinical Care Options
![טוויטר \ NatureRevClinOncol בטוויטר: "MET inhibitor tepotinib, like capmatinib, seems to have good activity in METexon14-altered advanced-stage NSCLC #ASCO19 #LCSM https://t.co/qKqnwgzFo5" טוויטר \ NatureRevClinOncol בטוויטר: "MET inhibitor tepotinib, like capmatinib, seems to have good activity in METexon14-altered advanced-stage NSCLC #ASCO19 #LCSM https://t.co/qKqnwgzFo5"](https://pbs.twimg.com/media/D8JPzyiXYAsolGe.jpg)
טוויטר \ NatureRevClinOncol בטוויטר: "MET inhibitor tepotinib, like capmatinib, seems to have good activity in METexon14-altered advanced-stage NSCLC #ASCO19 #LCSM https://t.co/qKqnwgzFo5"
![Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial - Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial -](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/e0616031-4f66-4ab5-b35f-c453d44e6fbe/gr2.jpg)
Tepotinib plus gefitinib in patients with EGFR-mutant non-small-cell lung cancer with MET overexpression or MET amplification and acquired resistance to previous EGFR inhibitor (INSIGHT study): an open-label, phase 1b/2, multicentre, randomised trial -
![Ivy Elkins on Twitter: "#Tepotinib in patient derived xenografts from #NSCLC brain metastases resulted in tumor regression, including complete responses. Potentially promising for patients with brain metastases with #METamp drivers. #AACR20 #lcsm @ Ivy Elkins on Twitter: "#Tepotinib in patient derived xenografts from #NSCLC brain metastases resulted in tumor regression, including complete responses. Potentially promising for patients with brain metastases with #METamp drivers. #AACR20 #lcsm @](https://pbs.twimg.com/media/EbM5yfsX0AAh3KB.jpg)
Ivy Elkins on Twitter: "#Tepotinib in patient derived xenografts from #NSCLC brain metastases resulted in tumor regression, including complete responses. Potentially promising for patients with brain metastases with #METamp drivers. #AACR20 #lcsm @
![Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: A review of preclinical and clinical studies - Cancer Treatment Reviews Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: A review of preclinical and clinical studies - Cancer Treatment Reviews](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/88c33a30-1781-4baa-9eae-b673fc22034a/gr1_lrg.jpg)
Capmatinib for patients with non-small cell lung cancer with MET exon 14 skipping mutations: A review of preclinical and clinical studies - Cancer Treatment Reviews
![The effect of tepotinib on c-MET, β-catenin, ERK, and c-MYC protein... | Download Scientific Diagram The effect of tepotinib on c-MET, β-catenin, ERK, and c-MYC protein... | Download Scientific Diagram](https://www.researchgate.net/publication/343802292/figure/fig1/AS:954140192681984@1604496157129/The-effect-of-tepotinib-on-c-MET-b-catenin-ERK-and-c-MYC-protein-levels-in-GC-cells.png)
The effect of tepotinib on c-MET, β-catenin, ERK, and c-MYC protein... | Download Scientific Diagram
![INSIGHT 2: a phase II study of tepotinib plus osimertinib in MET-amplified NSCLC and first-line osimertinib resistance | Future Oncology INSIGHT 2: a phase II study of tepotinib plus osimertinib in MET-amplified NSCLC and first-line osimertinib resistance | Future Oncology](https://www.futuremedicine.com/cms/10.2217/fon-2021-1406/asset/images/medium/figure2.gif)
INSIGHT 2: a phase II study of tepotinib plus osimertinib in MET-amplified NSCLC and first-line osimertinib resistance | Future Oncology
![SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations - ScienceDirect SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations - ScienceDirect](https://ars.els-cdn.com/content/image/1-s2.0-S2589004220310294-fx1.jpg)
SHP2 Inhibition Influences Therapeutic Response to Tepotinib in Tumors with MET Alterations - ScienceDirect
![Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases - Lung Cancer Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases - Lung Cancer](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/attachment/0a50763b-f46e-4053-8777-8bc74046836a/gr1.jpg)
Brain penetration and efficacy of tepotinib in orthotopic patient-derived xenograft models of MET-driven non-small cell lung cancer brain metastases - Lung Cancer
![Safety of Tepotinib in Patients with MET Exon 14 Skipping NSCLC and Recommendations for Management - Clinical Lung Cancer Safety of Tepotinib in Patients with MET Exon 14 Skipping NSCLC and Recommendations for Management - Clinical Lung Cancer](https://els-jbs-prod-cdn.jbs.elsevierhealth.com/cms/asset/76fcb8aa-4659-43c6-9a48-0a50df99462f/ga1.jpg)
Safety of Tepotinib in Patients with MET Exon 14 Skipping NSCLC and Recommendations for Management - Clinical Lung Cancer
![In silico docking of: (a) tepotinib (8) and TC-E 5001 (2) in MET; (b)... | Download Scientific Diagram In silico docking of: (a) tepotinib (8) and TC-E 5001 (2) in MET; (b)... | Download Scientific Diagram](https://www.researchgate.net/publication/337214116/figure/fig2/AS:824760489500674@1573649632464/n-silico-docking-of-a-tepotinib-8-and-TC-E-5001-2-in-MET-b-tepotinib-8-and.jpg)